Developing a Fast Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry Method for High-Throughput Surface Contamination Monitoring of 26 Antineoplastic Drugs

Growing attention on carcinogenicity and mutagenicity of antineoplastic drugs (ADs) from the International Agencies has led to present strict safe handling administration regulations. Accordingly, one most common ways assess occupational exposure these substances is identify quantify possible surface contamination inside hospital preparation units. Thus, it essential develop a fast high-throughput monitoring method capable identifying significant number ADs. The study reports developing UHPLC–MS/MS analysis screen 26 ADs through wipe test sampling. A Cortecs UPLC T3 50 × 2.1 mm (1.6 µm) column was selected perform analysis, using evaluations previous studies Product Quality Research Institute (PQRI) database. design experiments (DoE) methodological approach used optimize chromatographic conditions concerning best separation between all limits quantification for analytes were pg/mL ng/mL orders, turnaround time limited about 15 min. obtained accuracy mostly 90% 110% analytes, while precision under 10% low matrix effect observed said analytes. Only vindesine docetaxel presented lower performances.